SERD ZB716
An orally bioavailable selective estrogen receptor degrader/downregulator (SERD) and a structural analog of fulvestrant, with potential antineoplastic activity. Upon oral administration, SERD ZB-716 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.
| Synonym: | borestrant ERalpha-coregulator degrader ZB716 selective estrogen receptor alpha degrader ZB716 selective estrogen receptor degrader ZB716 |
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| Code name: | ZB 716 ZB-716 ZB716 |