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SERD ZB716

An orally bioavailable selective estrogen receptor degrader/downregulator (SERD) and a structural analog of fulvestrant, with potential antineoplastic activity. Upon oral administration, SERD ZB-716 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.
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Synonym:borestrant
ERalpha-coregulator degrader ZB716
selective estrogen receptor alpha degrader ZB716
selective estrogen receptor degrader ZB716
Code name:ZB 716
ZB-716
ZB716
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