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serdemetan

An orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. Serdemetan inhibits the binding of the HDM2–p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, this oncoprotein has been implicated in cancer cell proliferation and survival.

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Synonym:	HDM2 antagonist JNJ-26854165
Code name:	JNJ-26854165

serdemetan

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