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streptozocin

A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression.

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Synonym:	streptozotocin
US brand name:	Zanosar
Abbreviation:	STZ SZC SZN
Code name:	U-9889
Chemical structure:	2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose
IND number:	3859
NSC code:	85998

streptozocin

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