sulindac
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.
| Synonym: | Sulindac Sulfoxide |
|---|---|
| US brand name: | Aflodac Clinoril |
| Foreign brand name: | Algocetil Apo-Sulin Arthrocine Artribid Citireuma Clisundac Imbaral Novo-Sundac Reumofil Reumyl Sudac Sulinol Sulreuma |
| Abbreviation: | SULIN |
| Code name: | MK-231 |
| Chemical structure: | (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid |