Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

technetium Tc 99m anti-HER2 affibody HPArk2

A radioconjugate composed of an affibody targeting human epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2), labeled with technetium Tc 99m, with potential imaging activity using single photon emission computed tomography (SPECT)/computed tomography (CT). Upon administration, the anti-HER2 affibody moiety of technetium Tc-99m anti-HER2 affibody HPArk2 targets and binds to HER2-expressing tumor cells. Upon SPECT/CT imaging, HER2-expressing tumor cells can be detected. HER2, a receptor tyrosine kinase, is mutated in many tumor cell types and plays a key role in tumor cell proliferation and tumor vascularization.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:99mTc-HPArk2
99mTc-labeled HER2 affibody HPArk2
technetium Tc-99m anti-HER2 antagonist HPArk2
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search