tegafur
A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate.
| US brand name: | Florafur Fluorofur |
|---|---|
| Foreign brand name: | Citofur Coparogin Exonal Fental ftorafur Ftoral Ftoralon Fulaid Fulfeel Furafluor Furofutran Futraful Lamar Lifril Neberk Nitobanil Riol Sinoflurol Sunfural Tefsiel Utefos |
| Abbreviation: | FT |
| Code name: | FT-207 MJF-12264 WR-220066 |
| Chemical structure: | 5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione 5-fluoro-1-(tetrahydro-2-furyl)-uracil N1-(2'-furanidyl)-5-fluorouracil |
| IND number: | 10207 |
| NSC code: | 148958 |