teglarinad chloride
A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.
| Synonym: | apoptosis inducer GMX1777 |
|---|---|
| Code name: | GMX1777 |
| Chemical structure: | 4-({N-[6-(4-chlorophenoxy)hexyl]-N'-cyanocarbamimidoyl}amino)-1-(3-oxo- 2,4,7,10,13,16-hexaoxaheptadecan-1-yl)pyridinium chloride pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride |