temanogrel hydrochloride
The hydrochloride salt form of temanogrel, an orally bioavailable, selective inverse agonist of 5-hydroxytryptamine receptor 2A (5-HT2A), with potential anti-thrombotic and vasodilating activities. Upon oral administration, temanogrel targets, binds to and inhibits 5-HT2A expressed on platelet surfaces and in smooth muscle cells, thereby inhibiting 5-HT-mediated platelet aggregation and vasoconstriction. This may attenuate platelet aggregation and vasoconstriction, and improve blood flow.
| Synonym: | Temanogrel |
|---|---|
| Code name: | APD791 |
| Chemical structure: | 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-(morpholin-4-yl)ethoxy)phenyl)benzamide benzamide, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-(4-morpholinyl)ethoxy)phenyl)- |