NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: cell cycle inhibitor 779
rapamycin analog CCI-779
US brand name: Torisel Code name: CCI-779 Chemical structure: 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin