teniposide
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle.
| Synonym: | Thenvlidene-Lignan-P Thenylidene-Lignan-P VM26 |
|---|---|
| US brand name: | Vumon |
| Foreign brand name: | Vehem |
| Abbreviation: | EPT PTG |
| Code name: | VM-26 |
| Chemical structure: | [5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-Thenylidene-beta-D-glucopyranoside) 4'-Demethylepipodophyllotoxin-beta-D-thenylidine Glucoside |
| IND number: | 9336 |
| NSC code: | 122819 |