therapeutic progesterone
The therapeutic form of the naturally occurring hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy.
| Synonym: | progesterone |
|---|---|
| US brand name: | Colprosterone Lipo-Lutin Luteohormone Progestin Prolutin Proluton |
| Foreign brand name: | Corlutina Corluvite Cyclogest Gestiron Gestone Lutocyclin Lutocylin Lutocylin M Lutogyl Lutromone Progestasert Progesterol Progestogel Progestol Progeston Prolidon Syngesterone Utrogestan |
| Abbreviation: | PRG |
| Chemical structure: | 17alpha-hydroxy-6alpha-methylpregn-4-ene-3,20-dione delta4-pregnene-3,20-dione |
| NSC code: | 9704 |