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thiotepa

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A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.
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Synonym:thiofosfamide
thiophosphamide
thiophosphoamide
thiophosphoramide
triethylene thiophosphoramide
triethylenethiophosphoramide
US brand name:Tepadina
Tepylute
Abbreviation:TESPA
TSPA
Code name:SH 105
SH-105
SH105
WR 45312
Chemical structure:1,1',1''-phosphinothioyldynetrisaziridine
1,1',1"-phosphinothioylidynetrisaziridine
N,N',N''-triethylenethiophosphoramide
tris(1-aziridinyl)phosphine sulfide
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