thorium Th 227 anti-PSMA monoclonal antibody BAY 2315497
A radioimmunoconjugate consisting of a monoclonal antibody targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and labeled, via a 3-hydroxypyridin-2-one (3,2-HOPO) chelator, with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY 2315497 targets and specifically binds to PSMA on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing PSMA. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.
| Synonym: | PSMA-targeted thorium-227 conjugate BAY-2315497 PSMA-TTC BAY 2315497 targeted thorium conjugate BAY 2315497 Th 227 anti-PSMA monoclonal antibody BAY 2315497 thorium Th 227 monoclonal antibody BAY 2315497 thorium-227 anti-PSMA monoclonal antibody BAY 2315497 thorium-227 labeled immunoconjugate BAY-2315497 thorium-227-labeled antibody-chelator conjugate BAY 2315497 |
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| Code name: | BAY 2315497 BAY2315497 |