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thrombomodulin alfa

A recombinant, soluble form of the human protein thrombomodulin, with potential anticoagulant activity. Upon administration, thrombomodulin binds to thrombin, which stimulates the activation of protein C. Activated protein C (APC) degrades factor Va and Factor VIIa in the presence of the cofactor protein S, inhibits thrombin formation, and prevents both thrombin-mediated coagulation and further clot formation.
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Synonym:1-498-thrombomodulin (human clone TMP26/TMJ1 protein moiety reduced)
recomodulin
thrombomodulin (human 498-amino acid fragment)
Abbreviation:Tma
Code name:ART 123
ART-123
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