thrombomodulin alfa
A recombinant, soluble form of the human protein thrombomodulin, with potential anticoagulant activity. Upon administration, thrombomodulin binds to thrombin, which stimulates the activation of protein C. Activated protein C (APC) degrades factor Va and Factor VIIa in the presence of the cofactor protein S, inhibits thrombin formation, and prevents both thrombin-mediated coagulation and further clot formation.
| Synonym: | 1-498-thrombomodulin (human clone TMP26/TMJ1 protein moiety reduced) recomodulin thrombomodulin (human 498-amino acid fragment) |
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| Abbreviation: | Tma |
| Code name: | ART 123 ART-123 |