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tiazofurin

A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo.
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US brand name:Riboxamide
Abbreviation:TCAR
Chemical structure:2-beta-D-ribofuranosyl-4-thiazolecarboxamide
2-beta-D-ribofuranosylthiazole-4-carboxamide
IND number:21342
NSC code:286193
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