tilarginine
A pan-nitric oxide synthase (NOS) inhibitor, with potential immunomodulating and antineoplastic activities. Upon administration, tilarginine binds to and inhibits NOS, a free radical signaling molecule that promotes angiogenesis, metastasis, and immunosuppression in the tumor microenvironment (TME). Reduction in NOS activity may abrogate the immunosuppressive TME, enhance tumor antigen-specific immune response and inhibit tumor cell proliferation.
| Synonym: | N-methylarginine N5-(methylamidino)-L-ornithine NG-monomethyl-L-arginine omega-N-monomethylarginine targinine |
|---|---|
| Abbreviation: | L-NMMA NMA |
| IND number: | 8138 |
| NSC code: | 683245 |