TLR7 agonist RO7119929

An orally bioavailable Toll-like receptor (TLR) 7 agonist, with potential immunostimulating and antitumor activities. Upon oral administration, TLR7 agonist RO7119929 targets, binds to and activates TLR7. This may trigger the activation of cluster of differentiation (CD) 8-positive T cells, B cells, and innate immune cells including natural killer (NK) cells and macrophages, and may induce the production of cytokines including interferon alpha (IFNa), leading to antitumor activity. TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.