NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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tozasertib lactate
The lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:Aurora kinase inhibitor MK-0457
Code name:MK-0457
VX-680
Chemical structure:
  • N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2- yl]sulfanyl]phenyl]cyclopropanecarboxamide (2S)-2-hydroxypropanoate
  • propanoic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5- methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide