tozasertib lactate
The lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed.
AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis.
| Synonym: | Aurora kinase inhibitor MK-0457 |
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| Code name: | MK-0457 VX-680 |
| Chemical structure: | N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2- yl]sulfanyl]phenyl]cyclopropanecarboxamide (2S)-2-hydroxypropanoate propanoic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5- methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide |