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trabectedin

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A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate with potential antineoplastic activity. Binding to the minor groove of DNA, trabectedin inteferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks.and blocks the cell cycle in the G2 phase.
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Synonym:ecteinascidin
US brand name:Yondelis
Foreign brand name:Yondelis
Abbreviation:ET 743
NSC code:648766
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