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ado-trastuzumab emtansine

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An antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers.
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Synonym:ado trastuzumab emtansine
trastuzumab emtansine
trastuzumab-DM1
trastuzumab-MCC-DM1
trastuzumab-MCC-DM1 antibody-drug conjugate
trastuzumab-MCC-DM1 immunoconjugate
US brand name:Kadcyla
Abbreviation:T-DM1
Code name:PRO132365
RO5304020
Chemical structure:immunoglobulin G1, anti-(human p185neu receptor) (human-mouse monoclonal RhuMab HER2 gamma1-chain), disulfide with human-mouse monoclonal RhuMab HER2 light chain, dimer, tetraamide with N2'-(3-((1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)thio)-1-oxopropyl)-N2'-deacetylMaytansine
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