trilostane
A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone.
| US brand name: | Modrastane |
|---|---|
| Foreign brand name: | Desopan Modrenal |
| Code name: | WIN 24,540 WIN 24540 |
| Chemical structure: | (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile 2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one 4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile |