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trilostane

A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone.
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US brand name:Modrastane
Foreign brand name:Desopan
Modrenal
Code name:WIN 24,540
WIN 24540
Chemical structure:(4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one
4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile
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