Trimethoprim-Sulfamethoxazole
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as Co-Trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthase.
| Synonym: | Bactrimel Centran Centrin cotrimoxazole Eslectin insozalin trimedin Trimethoprim/Sulfamethoxazole trimezole |
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| US brand name: | Bactrim Bactrim DS Cotrim Septra Sulfamethoprim Sulfatrim Sulmeprim Uroplus |
| Abbreviation: | SMZ-TMP TMP-SMX |
| NSC code: | 618652 |