Skip to main content

Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Trimethoprim-Sulfamethoxazole

A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as Co-Trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthase.

Check for active clinical trials using this agent View this agent in the NCI Thesaurus

Synonym:	Bactrimel Centran Centrin cotrimoxazole Eslectin insozalin trimedin Trimethoprim/Sulfamethoxazole trimezole
US brand name:	Bactrim Bactrim DS Cotrim Septra Sulfamethoprim Sulfatrim Sulmeprim Uroplus
Abbreviation:	SMZ-TMP TMP-SMX
NSC code:	618652

Trimethoprim-Sulfamethoxazole

Search NCI's Drug Dictionary