autologous genetically-modified MAGE-A4 C1032 CD8alpha T cells
Autologous human T lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4) and the CD8alpha co-receptor, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 CD8alpha T cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T cells into CD8+ cytotoxic T cells.
Synonym: | ADP-A2M4CD8 autologous genetically-modified MAGE-A4 C1032 CD8alpha T lymphocytes autologous genetically-modified melanoma antigen A4 CD8alpha T cells autologous MAGE-A4 C1032 TCR-modified CD8alpha T cells autologous TCR-transduced MAGE-A4 C1032 CD8alpha T cells MAGE-A4 SPEAR CD8alpha T cells MAGE-A4 SPEAR CD8alpha T-cells MAGE-A4-specific TCR gene-transduced C1032 CD8alpha T lymphocytes MAGE-A4-specific TCR gene-transduced C1032 CD8alpha T-lymphocytes SPEAR T-cell ADP-A2M4CD8 |
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