vadimezan
A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.
| Synonym: | Dimethyloxoxanthene Acetic Acid |
|---|---|
| Abbreviation: | 5,6-MexXAA DMXAA |
| Code name: | AS1404 ASA404 |
| Chemical structure: | 5,6-Dimethylxanthenone-4-Acetic Acid |