vitamin D3 analogue ILX23-7553
A vitamin D3 analogue with potential antineoplastic activity. ILX23-7553 binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, ILX23-7553 may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.
| Synonym: | 16-23-D3 |
|---|---|
| Code name: | BXL 353 ILEX 23-7553 ILX 237553 ILX-237553 ILX23 7553 ILX23-7553 ILX237553 RO 237553 RO-237553 Ro23-7553 RO237553 |
| Chemical structure: | 1,25-dihydroxy-16-ene-23-yne-cholecalciferol 9,10-secocholesta-5,7,10(19),16-tetraen-23-yne-1,3,25-triol, (1alpha,3beta,5Z,7E)- |