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zalcitabine

A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death.
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Synonym:dideoxycytidine
US brand name:Hivid
Abbreviation:ddC
Chemical structure:2',3'-dideoxycytidine
IND number:28975
30858
33134
NSC code:606170
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