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zamtocabtagene autoleucel

A preparation of autologous CD4/CD8 enriched T lymphocytes engineered to express pLTG1497, a tandem chimeric antigen receptor (CAR) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, zamtocabtagene autoleucel target and bind to CD19- and CD20-expressing tumor B cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse.
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Synonym:autologous anti-CD20/CD19-targeting tandem CAR T cells MB-CART2019.1
autologous pLTG1497-transduced CAR T cells MB-CART2019.1
Code name:MB CART2019.1
MB-CART2019.1
MBCART2019.1
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