zidovudine
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.
| Synonym: | azidothymidine |
|---|---|
| US brand name: | Retrovir |
| Foreign brand name: | Aztec |
| Abbreviation: | AZT ZDV |
| Code name: | BW-A509U |
| Chemical structure: | 3'-azido-3'-deoxythymidine |
| IND number: | 26635 30858 33134 34545 35782 |
| NSC code: | 602670 |