NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- staphylococcus aureus protein A
A protein that resides in the microbial wall of staphylococcus aureus and interferes with opsonization by binding to the Fc portion of immunoglobulin. The protein has a deleterious effect on the epithelial cells that line the respiratory tract, and plays a role in the induction of pneumonia. Protein A also initiates polymorphonuclear cell migration into airway passages via TNFR1 activation. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: S. aureus protein A
Staph. Protein A