6-azauridine
A synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis.
| Synonym: | 6-azauracil riboside azauridine riboazauracil |
|---|---|
| Abbreviation: | 6-AZUR |
| Chemical structure: | 1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl 2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H, 4H)-dione 2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione 3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside 6-azauracil 1-riboside 6-azauracil-.beta.-D-riboside 6-azauracil-beta-D-riboside 6-azauracilriboside |