3-deazauridine
A synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position. 3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells.
| Synonym: | deazauridine |
|---|---|
| Chemical structure: | 2(1H)-pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl 4-hydroxy-1-(beta-D-ribopentofuranosyl)-2-pyridone |
| IND number: | 12540 |
| NSC code: | 126849 |