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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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ethinyl estradiol
A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Estinyl
Ethinoral
Feminone
Orestralyn
Foreign brand name:Diogyn E
Eticylol
Inestra
Lynoral
Abbreviation:EE
Chemical structure:(17alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol