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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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floxuridine
A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:FdUrD
floxuridin
fluorodeoxyuridine
fluorouridine deoxyribose
fluoruridine deoxyribose
US brand name:FUDF
Abbreviation:5-FUDR
FDUR
FUdR
Code name:WR-138720
Chemical structure:
  • 1-(2-deoxy-beta-D-ribofuranosyl)-5-fluorouracil
  • 2'-deoxy-5-fluorouridine
  • 5-fluoro-2'-deoxy-beta-uridine
  • 5-fluoro-2'-deoxyuridine
  • 5-fluorodeoxyuridine
  • 5-fluorouridine deoxyribose