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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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trimethoprim-sulfamethoxazole
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as co-trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthetase. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:cotrimoxazole
Eslectin
insozalin
trimedin
trimezole
US brand name:Bactrim
Cotrim
Septra
Sulfamethoprim
Sulfatrim
Sulmeprim
Abbreviation:SMZ-TMP
TMP-SMX