Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

chlorpromazine

A phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Chlorpromazine appears to exert its anti-emetic activity by blocking the dopamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
US brand name:Thorazine
Foreign brand name:Chlor-PZ
Chemical structure:2-chloro-10-(3-(dimethylamino)propyl)phenothiazine
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search