flutamide
View Patient InformationA toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression.
| Synonym: | Flucinom Flugerel Niftolide |
|---|---|
| Foreign brand name: | Apimid Cebatrol Chimax Cytomid Drogenil Euflex Eulexine Flucinome Fluken Flulem Fluta-Gry Flutabene Flutacan Flutamex Flutamin Flutan Flutaplex Fugerel Grisetin Oncosal Profamid Prostacur Prostadirex Prostica Prostogenat Tafenil Tecnoflut Testotard |
| Abbreviation: | FLUT |
| Code name: | Sch 13521 |
| Chemical structure: | 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide 4'-nitro-3'-trifluoromethylisobutyranilide alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide |
| IND number: | 25378 |
| NSC code: | 147834 215876 |