NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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flutamide

A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for using this agent. ()

Synonym:	Flucinom Flugerel Niftolide
Foreign brand name:	Apimid Cebatrol Chimax Cytomid Drogenil Euflex Eulexine Flucinome Fluken Flulem Flutabene Flutacan Fluta-Gry Flutamex Flutamin Flutan Flutaplex Fugerel Grisetin Oncosal Profamid Prostacur Prostadirex Prostica Prostogenat Tafenil Tecnoflut Testotard
Abbreviation:	FLUT
Code name:	Sch 13521
Chemical structure:	2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide 4'-nitro-3'-trifluoromethylisobutyranilide alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide