hydrocortisone sodium succinate
The sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation.
| Synonym: | cortisol sodium succinate Hycorace Hydrocortisone 21-Sodium Succinate Hydrocortisone Na succinate Nordicort Sodium hydrocortisone succinate Solu-Cortef Solu-Glyc |
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| US brand name: | A-Hydrocort Emergent-EZ Solu-Cortef |
| Foreign brand name: | Buccalsone Corlan Cortop Efcortelan Flebocortid Hidroc Clora Hydro-Adreson Hydrocort Kinogen Nordicort Nositrol Sinsurrene Solu-Glyc |
| Abbreviation: | HDC |
| Chemical structure: | (11beta)-21-(3-carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, monosodium salt |