ifosfamide
View Patient InformationA synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.
| Synonym: | Ifomide Iphosphamid iphosphamide Iso-Endoxan Isoendoxan isophosphamide Naxamide |
|---|---|
| US brand name: | Ifex |
| Foreign brand name: | Holoxan Holoxane IFO-Cell Ifolem Ifomida Ifoxan Mitoxana Tronoxal |
| Abbreviation: | IFF IFO IFX IPP |
| Code name: | Asta Z-4942 MJF-9325 Z-4942 |
| Chemical structure: | 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide |
| IND number: | 7887 |
| NSC code: | 109724 |