NCI Drug Dictionary

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

Browse:
dapsone
A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:croysulfone
diphenasone
dumitone
novophone
sulfona-mae
sulphadione
US brand name:Aczone
Avlosulfon
Disulone
Foreign brand name:Eporal
Undolac
Abbreviation:DADPS
DDS
Code name:1358F
Chemical structure:
  • 4,4'-sulfonylbisbenzamine
  • 4,4'-sulfonylbisbenzeneamine
  • 4,4'-sulfonyldianiline
  • bis(4-aminophenyl)sulfone