tretinoin
A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties.
| Synonym: | all-trans retinoic acid all-trans vitamin A acid beta-retinoic acid retinoic acid TRA trans retinoic acid trans vitamin A acid tretinoinum Vitamin A Acid |
|---|---|
| US brand name: | Aberel Aknoten Avita Renova Retin-A Retin-A MICRO Vesanoid |
| Foreign brand name: | Airol Cordes Vas Dermairol Epi-Aberel Eudyna Retisol-A Stieva-A Stieva-A Forte Vitinoin |
| Abbreviation: | ATRA |
| Acronym: | ATRA TRA |
| Code name: | Ro 5488 |
| Chemical structure: | (All-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid |
| IND number: | 34987 |
| NSC code: | 122758 |