becatecarin
A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis.
| Synonym: | DEAE-rebeccamycin rebeccamycin analogue rebeccamycin analogue, tartrate salt |
|---|---|
| Code name: | BMS-181176 BMY-27557-14 XL119 |
| Chemical structure: | 5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)- |
| IND number: | 46941 |
| NSC code: | 655649 |