perillyl alcohol
A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle.
| Synonym: | dihydrocuminyl alcohol perilla alcohol perillic alcohol perillol |
|---|---|
| Abbreviation: | POH |
| Code name: | NEO100 |
| Chemical structure: | (S)-(-)-perillyl alcohol 1-cyclohexene-1-methanol 4-(1-methylethenyl)-1-cyclohexene-1-methanol 4-isopropenylcyclohex-1-ene-1-methanol p-mentha-1,8-dien-7-ol |
| IND number: | 47472 |
| NSC code: | 641066 |