gimeracil
A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.
| Synonym: | chlorodihydroxypyridine |
|---|---|
| Abbreviation: | CDHP |
| Chemical structure: | 5-chloro-2,4-dihydroxypyridinediol |