LMB-7 immunotoxin
A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2.
| Synonym: | B3(Fv)-PE38 B3(Fv)-PE38 Immunotoxin HB21(Fv)PE40 immunotoxin LMB-7 LMB-7 (Single-Chain Immunotoxin) |
|---|---|
| IND number: | 5863 |
| NSC code: | 658931 659639 |