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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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thiotepa
Patient Information
A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:thiofosfamide
thiophosphamide
thiophosphoramide
triethylene thiophosphoramide
Foreign brand name:tepadina
Abbreviation:TSPA
Code name:WR 45312
Chemical structure:
  • 1,1',1"-phosphinothioylidynetrisaziridine
  • 1,1',1''-phosphinothioyldynetrisaziridine
  • N,N',N''-triethylenethiophosphoramide
  • tris(1-aziridinyl)phosphine sulfide