NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- nelarabine
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An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: Arranon Code name: 506U78
GW506U78Chemical structure: - 2-amino-6-methoxypurine arabinoside
- 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine