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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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tenofovir
A synthetic antiviral acyclic nucleotide analogue of adenosine 5-monophosphate. Tenofovir is incorporated into human immunodeficiency viral DNA instead of the natural substrate deoxyadenosine 5-triphosphate, thereby inhibiting HIV-1 reverse transcriptase (RT), an RNA-dependent DNA polymerase, and resulting in DNA chain termination and impairment of viral replication and propagation. This agent prevents HIV from reproducing in uninfected cells only. Tenofovir exhibits activity against the hepatitis B virus (HBV). Check for active clinical trials using this agent. (NCI Thesaurus)