NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- fluorine F 18 fluciclovine
A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, fluorine F 18 fluciclovine (FACBC) appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occuring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, FACBC accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET). Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: anti-1-amino-3-[18F ]fluorocyclobutane-1-carboxylic acid