NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- 3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine
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A hapten-carrier immunoconjugate composed of the hapten trans-3′-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is not
immunogenic, must be haptenized and conjugated to a carrier
protein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminium
hydroxide may be used as an adjuvant for this vaccine. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: nicotine conjugate vaccine US brand name: NicVax