NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: Vermox Foreign brand name: Ovex Code name: R 17635 Chemical structure:
- (5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester
- Methyl 5-benzoyl benzimidazole-2-carbamate